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Caihua Ni

2019-04-07  点击:[]


Office: A427

Phone: 13382888295



2004-2017 Working at School of Chemicai and Material Engineering, Jiangnan university;

1982-2003 Working at Department of Chemistry, Changjiang university;

1997-1999 Working at Botswana as a teacher.

2001-2002 Visiting scholar at Montreal university, Canada.


2003-2006 Study for PhD, Institute of Polymer chemistry and physics, Nankai university;

1985-1988 Study for Master degree, Department of Chemistry, Wuhan university;

1978-1982 Study at Department of Chemistry, Jingzhou teachers college;


Research interests focus on natural polymer materials, biodegradable materials, hydrogels and applications, medical materials and applications, adsorption resins and their application in wastewater treatment. Complete projects: Preparation and Industrialization of Medical anti-adhesion agent based on complex of modified chitosan.( Jiangsu Science and Technology Support Program – Industrial). Synthesis of sodium alginate modified chelate flocculant and its treatment of industrial wastewater, Preparation of magnetic alginate flocculant and its rapid purification water treatment (State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering).


Has taught courses: Organic chemistry, polymer chemistry, Advanced polymer chemistry, environmentally friendly polymer materials.

Earn rewards:

1. First prize of technological progress. Light Industry Federation of China. 2016. Based

on functional flocculants and application in key technologies of Sewage Treatment.

2. First prize of Science and Technology Progress Award, Chamber of Commerce of China. 2015. Preparation of Biodegradable Polymer Adsorbent and Its Application in Water Resources Protection.

Publications as corresponding author recently:

[1]Yuanyuan Ding, Liping Zhang, Gang Shi, Xinxin Sang, Caihua Ni. Preparations and doxorubicin controlled release of amino-acid based redox/pH dual-responsive nanomicelles. Materials Science and Engineering C 77 (2017) 920–926

[2] Liping Zhang, Yamin Zhou, Gang Shi, Xinxin Sang, Caihua Ni. Preparations of hyperbranched polymer nano micelles and the pH/redox controlled drug release behaviors. Materials Science and Engineering C doi: 10.1016/j.msec.2017.05.027

[3] L. Wu, C. Ni, L. Zhang, G. Shi, X. Bai, Y. Zhou, F. He. Surface Charge Convertible and Biodegradable Synthetic Zwitterionic Nanoparticles for Enhancing Cellular Drug Uptake. Macromolecular Bioscience, 2016, 16, 308-313.

[4] LuyanWu, Liping Zhang, Gang Shi, Caihua Ni . Zwitterionic pH/redox nanoparticles based on dextran as drug carriers for enhancing tumor intercellular uptake of doxorubicin. Materials Science and Engineering C 2016, 61, 278–285

[5] Liping Zhang, Jie Wang, Caihua Ni, Yanan Zhang, Gang Shi. Preparation of polyelectrolyte complex nanoparticles of chitosan and poly(2-acry1amido- 2-methylpropanesulfonic acid) for doxorubicin release. Materials Science and Engineering C 2016, 58, 724–729

[6] Liping Zhang, Lin Xi, Gang Shi, Changping Zhu, Caihua Ni. Reduction-responsive zwitterionic nanogels based on carboxymethyl chitosan for enhancing cellular uptake in drug release. Colloid Polym Sci 2016, 294, 629–637

[7]Luyan Wu, Caihua Ni, Liping Zhang & Gang Shi.Preparation of pH-sensitive zwitterionic nano micelles and drug controlled release for enhancing cellular uptake. Journal of Biomaterials Science, Polymer Edition.2016, 27 (7), 643–656.

[8] Yanan Zhang, Caihua Ni, Gang Shi, Jie Wang, Meng Zhang, Wang Li. The polyion complex nano-prodrug of doxorubicin (DOX) with poly(lactic acid-co-malic acid)-block-polyethylene glycol: preparation and drug controlled release.Med. Chem. Res. 2015, 24, 1189-1195.

[9] Caihua Ni, Ronghui Lu,Lei Tao,Gang Shi.Xuejun Li, Changhu Qin. Synthesis of poly(vinyl alcohol-graft-lactic acid) copolymer and its application as medical anti-tissue adhesion thin film. Polym. Bull. 2015, 72:1515–1529

[10] Gang Shi, Yuanyuan Ding, Xin Zhang, Luyan Wu, Fei He Caihua Ni. Drug release behavior of poly (lacticglycolic acid) grafting from sodium alginate (ALG-g-PLGA) prepared by direct polycondensation。Journal of Biomaterials Science, Polymer Edition, 2015,26(16), 1152-1162

[11]Gang Shi, Youxin Che, Yamin Zhou, Xue Bai,Caihua Ni. Synthesis of polyglycolic acid grafting from sodium alginate through direct polycondensation and its application as drug carrier. J Mater Sci (2015) 50:7835–7841

[12] Gang Shi, Xishun Li, Zhiyun Feng, Luyan Wu & Caihua Ni. Preparation of Poly(N-butyl methacrylateco-glycidyl methacrylate) and Toughness Improvement for Powder Epoxy Resin E663. Polymer-Plastics Technology and Engineering, 2015, 54: 881–888

[13] Jie Wang, Caihua Ni, Yanan Zhang, Meng Zhang, Wang Li, Bolong Yao, Liping Zhang. Preparation and pH controlled release of polyelectrolyte complex of Poly(L-malic acid-co-D,L-lactic acid) and chitosan. Colloids and Surfaces B: Biointerfaces.2014, 115, 275– 279

[14] Xishun Li, Caihua Ni, Fuwen Ma, Bolong Yao,Changping Zhu. Preparationofpoly(n-butyl acrylate-co-glycidyl methacrylate) and its application in enhancement of epoxy resin. Polymer-Plastics Technology & Engineering. 2014,53: 262–267

[15]Hong Cai, Caihua Ni, Liping Zhang. Preparation and salt-responsive drugcontrolled release of complex nanoparticles of poly[(2-dimethylamino) ethyl methacrylate] and Alginic acid. Journal of Controlled Release 2013, 172, e34-e35.

[16]Caihua Ni, Hong Cai, Longhua Yuan. Polyion complex micelles based on poly[(2-dimethylamino) ethyl methacrylate-co-diacetone acrylamide] and alginic acid: Preparation, characterization and pH-controlled doxorubicin release. Journal of Controlled Release 2013, 172, e16–e17
[17]Min Wu, Caihua Ni, Bolong Yao, Changping Zhu, Bo Huang, Liping Zhang,Covalently Cross-Linked and Hydrophobically Modified Alginic Acid Hydrogels and Their Application as Drug Carriers. Polymer Engineering and Science 2013. 53, 1583–1589

[18]Hongwu Zhang,Yanbin Cai,Changping Zhu,Bo Huang,Bolong Yao&Caihua Ni, Degradation of Alginate and Polymerization of Styrene Initiated by Alginate Macroradicals under Ultrasonic Irradiation. International Journal of Polymeric Materials and Polymeric Biomaterials , 2013,62(1), 50-55.

[19] H. Cai & C.H. Ni & B.L. Yao & L.P. Zhang,C.P. Zhu. A new kind of polyion complex nanoparticles and the covalent drug-loading pattern for doxorubicin and pH-controlled release. Colloid Polym. Sci. 2013,291:2843–2850

[20]Hong Cai, Caihua Ni, Liping Zhang.Preparation of complex nano-particles based on alginic acid/poly[(2-dimethylamino) ethyl methacrylate] and a drug vehicle for doxorubicin release controlled by ionic strength. European Journal of Pharmaceutical Sciences 2012, 45, 43–49

[21]Qingbin Meng, Yingying Kou, Xin Ma, Yuanjun Liang, Lei Guo, Caihua Ni, and Keliang Liu.Tunable Self-Assembled Peptide Amphiphile Nanostructures

Langmuir,2012,28(11), pp 5017–5022

[22] Zhiyun Feng, Yi Zhu and Caihua Ni. Preparation of Composites of Silica/ PNIPAm by Coupling Reaction and Their Application in HPLC International Journal of Polymer Anal. Charact., 2012, 17: 61–71.

[23] Xiaoqian Chen, Ronghui Lu, Duo Meng, Yao Rong, Bolong Yao, Caihua Ni. Preparation and Characterization of Magnetic Star-Shaped Amphiphilic Copolymer Nanoparticles of S-Fe3O4-PLA-b-MPEG. Polymer Composites. 2012, 33: 2134–2139.

[24] Zhiqiang Xu, Caihua Ni , Bolong Yao , Lei Tao, Changping Zhu, Qingbang Han, Jiaquan Mi. The preparation and properties of hybridized hydrogels based on cubic thiol-functionalized silsesquioxane covalently linked with poly (N-isopropylacrylamide). Colloid Polym Sci 2011, 289:1777–1782

[25] Caihua Ni , Guifeng Ni, Liping Zhang , Jiaquan Mi, Bolong Yao , Changping Zhu. Syntheses of silsesquioxane (POSS)-based inorganic/organic hybrid and the application in reinforcement for an epoxy resin. Journal of Colloid and Interface Science 2011,362,94–99.
[26] J.G.Yu, X.Q.Hu, Y.N.Zeng, L.P.Zhang, C.H.Ni, X.Hao, W.H.Sun. Synthesis, characterisation and ethylene oligomerization behaviour of N-(2-substituted-5,6,7- trihydroquinolin -8-ylidene) arylamino nickel dichlorides. New Journal of Chemistry. 2011, 35, 187-183

[27] C.P. Zhu, B. Huang, Q.B. Han, C.H. Ni, G.J. Zhu, M.H. Liu, M.L.Shan. Frequency effect on p-nitrophenol degradation under conditions of strict acoustic and electric control. Water Science and Engineering 2011, 4(1) , 74-82.

[28]Changping Zhu, Zupeng Chen, Caihua Ni, Jiangang Yu, Bo Huang, and

Minlei Shan. Degradation of Sodium Polystyrene Sulfonate and the Radical Initiated Polymerization of Styrene Under Ultrasonic Irradiation. Polymer-Plastics Technology and Engineering, 2011, 50: 1262–1265

[29] Caihua Ni,Geng Wu,Changping Zhu, and Bolong Yao. The Preparation and Characterization of Amphiphilic Star Block Copolymer Nano Micelles Using Silsesquioxane As the Core. J. Phys. Chem. C 2010, 114, 13471–13476
[30] Caihua Ni,Guifeng Ni et al.The preparation of inorganic/organic hybrid nanomaterials Containing silsesquioxane and its reinforcement For an epoxy resin network. Colloid Polym Sci 2010, 288:469–477
[31] Caihua Ni,Guangjun Zhu, Changping Zhu,Bolong Yao,D.N.T.Kumar Studies on core–shell structural nano-micelles Based on star block copolymer of poly(lactide) And poly(2-(dimethylamino)ethylmethacrylate) Colloid Polym Sci 2010, 288:1193–1200
[32] Bolong Yao, Caihua Ni, Cheng Xiong, Changping Zhu, Bo Huang. Hydrophobic modification of sodium alginate and its application in drug controlled release. Bioprocess Biosyst Eng 2010, 33:457–463
[33] Caihua Ni, Wentao Wang, Changping Zhu, Bolong Yao. Grafting Polymerization of N-isopropylacrylamide on the Surfaces of Silica by ATRP and Its Application in HPLC. Soft Materials, 2010, 8(1):14–28
[34] Bolong Yao, Cheng Yang, Kun Zhang, Zhongbin Ni, Caihua Ni, Mingqing Chen

Studies on Syntheses and Dynamic Swelling Kinetics of pH-Sensitive Macro-porous Poly (N-isopropylacrylamide-co-acrylic acid) Hydrogels,Polymer Science Ser.A, 2010, 52, 19–25

Authorized patents

[1] Ni et al. Preparation and Application of Amphiphilic Modified Chitosan Complex. ZL 201210067410.9

[2] Ni et al. Preparation of alginate and poly - diacetone acrylamide interpenetrating network. ZL 201110262866.6

[3] Ni et al.Preparation of Polycaprolactone and Polyethylene Glycol Amphiphilic Copolymer by Degradation. ZL 201110393756.3

[4] Ni et al. Synthesis of Alginate - Polystyrene Copolymer by Ultrasonic Method. ZL 201110335451.7

[5] Ni et al. Preparation of Modified Alginate and Its Gel Microspheres. ZL 201110262863.2

[6] Ni et al. Synthesis of a Thermosensitive Inorganic / Polymer Hybrid. ZL201010571722.4

[7] Ni et al. A New Method for Preparing Micelles by Polymer Composite. ZL 201110262855.8

[8] Ni et al. A Synthetic Method of Modified Alginate Flocculant and Its Application. ZL 201210087121.5

[9] Ni et al. Preparation of POSS / polylactic acid and poly (N - isopropylacrylamide) star block copolymer. ZL 201110335384.9

[10] Ni et al. Preparation of Covalent Crosslinking and Hydrophobically Modified Alginate Hydrogels by One Step. ZL 201110393776.0

[11] Ni et al. Preparation of Three - component Polymer Micelles by One – pot. ZL 201110335423.5

[12] Ni et al. A kind of embolic microspheres containing ion - exchange functional groups. ZL 201410547365.6

[13] Ni et al. A preparation method of pH sensitive inorganic high polymer hybrid hydrogel. ZL 201210460744.2

[14] Ni et al. Preparation of Magnetic Resistant Star Block Copolymer Nanoparticles. ZL 201210087040.5

[15] Ni et al. A kind of epoxy functional group - containing hybrid polymer epoxy resin nano - enhancer. ZL 201410612454.4

[16] Ni et al. A novel structure of nano-gold colloid and its preparation method, ZL 201310282563.X

[17] Ni et al. Preparation of polyelectrolyte terpolymer and its nanometer micelles, ZL 201310282561.0

[18] Ni et al. Preparation of Nanometer Micelles Containing Double Reactivity Polymer, ZL 201410546530.6

[19] Ni et al. a polyglutamic acid and cystine based on the pH and reducing the sensitivity of nano-microgels. ZL 201410724506.7

[20] Ni et al. Preparation and Application of Heavy Metal Ion Adsorbent. ZL 201510262299.2

[21] Ni et al. Preparation of modified carboxymethyl chitosan nanogels. ZL 201510244424.7

[22] Ni Caihua, Xi Lin, Zhang Liping, etc.: a pH and redox dual sensitive nanoparticles. ZL 201410613804.9

[23] Ni et al. Preparation of magnetic response star - type block copolymer nano - micelles as drug carrier. ZL 201310127188.1

[24] Ni et al. A modified sodium alginate flocculant with magnetic properties. ZL 201210460743.8

[25] Ni et al. Synthesis and Application of a Novel Nano - hybrid. ZL 201310282079.7

[26] Ni et al. Preparation of a porous high - swellable gelatin microspheres. ZL 201410395973.X

[27] Ni et al. A pH and Redox dual Sensitive Nanoparticles. ZL 201410613804.9

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